Benzyl Bromide → N-Benzylnormechlorethamine
反応式
Cl.[Cl:2][CH2:3][CH2:4][NH:5][CH2:6][CH2:7][Cl:8].[CH2:9](Br)[C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1.C(N(CC)CC)C>CN(C=O)C>[Cl:2][CH2:3][CH2:4][N:5]([CH2:9][C:10]1[CH:15]=[CH:14][CH:13]=[CH:12][CH:11]=1)[CH2:6][CH2:7][Cl:8]参加物
5
実験手順
An ice bath is used to cool a mixture of 150 g of N,N-bis(2-chloroethyl)amine hydrochloride and 100 ml of benzyl bromide in 1000 ml of DMF and then 120 ml of triethylamine are added dropwise and the mixture is left with stirring at AT overnight. The reaction mixture is concentrated under vacuum, the residue is taken up in water and extracted 3 times with ether, the organic phases are dried over Na2SO4 and the solvent is evaporated under vacuum. This gives 113 g of the expected product.
後処理
- customAn ice bath is used
- temperatureto cool
- waitthe mixture is left
- concentrationThe reaction mixture is concentrated under vacuum
- extractionextracted 3 times with ether
- dry with materialthe organic phases are dried over Na2SO4
- customthe solvent is evaporated under vacuum
出典と根拠
- ORDレコード
- ord-a9bfd6e512c14c1f87f97806cb513292
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07423039B2
反応ノート
読み込み中…