2-(4-Fluorophenyl)acetic acid → 8-(4-Fluorobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine

HRID 29864

反応式

HRID 29864 の反応式
[F:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][C:9](O)=O)=[CH:4][CH:3]=1.[NH2:12][C:13]1[C:14](=[O:35])[N:15]([CH2:32][CH2:33][CH3:34])[C:16](=[O:31])[N:17]([CH2:20][CH2:21][C:22]2[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=2)[C:18]=1[NH2:19]>>[F:1][C:2]1[CH:3]=[CH:4][C:5]([CH2:8][C:9]2[NH:12][C:13]3[C:14](=[O:35])[N:15]([CH2:32][CH2:33][CH3:34])[C:16](=[O:31])[N:17]([CH2:20][CH2:21][C:22]4[CH:27]=[CH:26][C:25]([N+:28]([O-:30])=[O:29])=[CH:24][CH:23]=4)[C:18]=3[N:19]=2)=[CH:6][CH:7]=1

参加物

3

反応物 2

HCID 98372-(4-Fluorophenyl)acetic acidHCID 116096655,6-Diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil

生成物 1

HCID 184495398-(4-Fluorobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine

実験手順

By the method of Example 2, 4-fluorophenylacetic acid is reacted with 5,6-diamino-1-[2-(4-nitrophenyl)ethyl]-3-propyluracil (6) to yield 8-(4-fluorobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine. By methods well known in the art, 8-(4-fluorobenzyl)-3-[2-(4-nitrophenyl)ethyl]-1-propylxanthine is reduced with hydrazine hydrate or hydrogen gas in the presence of a palladium catalyst to yield 3-[2-(4-aminophenyl)ethyl]-8-(4-fluorobenzyl)-1-propylxanthine.

出典と根拠

ORDレコード
ord-d68a98ef2c574e1eaa69d80a7f357686
出典データセット
uspto-grants-2008_09
特許番号
US07423041B2

関連ノート

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