Hydrochloric Acid → Piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride

HRID 29883ノート

反応式

HRID 29883 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([C:14](=[O:30])[NH:15][C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][C:23]3[CH:28]=[CH:27][C:26]([F:29])=[CH:25][CH:24]=3)[CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:31]>O1CCOCC1>[ClH:31].[F:29][C:26]1[CH:27]=[CH:28][C:23]([O:22][C:18]2[CH:17]=[C:16]([NH:15][C:14]([CH:11]3[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]3)=[O:30])[CH:21]=[CH:20][CH:19]=2)=[CH:24][CH:25]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 692223994-[3-(4-Fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester

生成物 1

HCID 86607288Piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride収率 96%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒

実験手順

4-[3-(4-fluoro-phenoxy)-phenylcarbamoyl]-piperidine-1-carboxylic acid tert-butyl ester (15 g, 0.036 mol) was dissolved in 4 N HCl in dioxane (160 mL) and stirred overnight at room temperature. The volume of the reaction was reduced to remove most of the dioxane and the residue was filtered to afford piperidine-4-carboxylic acid [3-(4-fluoro-phenoxy)-phenyl]-amide hydrochloride (11.7 g, 96%) as a white solid.

後処理

  1. customto remove most of the dioxane
  2. filtrationthe residue was filtered

出典と根拠

ORDレコード
ord-df0ca034e999438b96d35e807db3cd9d
出典データセット
uspto-grants-2008_09
特許番号
US07423043B2

反応ノート

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