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HRID 29897作成日：2026年10月25日

Methyl 4-(bromomethyl)benzoate → 4-({[2-(4-Chlorophenyl)-6-phenylpyrimidin-4-yl]oxy}methyl)benzoic acid

https://huagongshe.com/reaction/29897

反応式

関与物質

役割名称HCID仕込み量
反応物Methyl 4-(bromomethyl)benzoateHCID 256687—
反応物HCID 178515558HCID 178515558—
生成物4-({[2-(4-Chlorophenyl)-6-phenylpyrimidin-4-yl]oxy}methyl)benzoic acidHCID 69197248—

反応手順

The title compound was prepared from 2-(4-chloro-phenyl)-6-phenyl-pyrimidin-4-ol (which was obtained in Intermediate 1) and methyl 4-(bromomethyl)benzoate according to Method A and Method B; 1H NMR (DMSO-d6, 300 MHz) δ 5.61 (s, 2H), 7.26 (t, J=9.0 Hz, 2H), 7.45-7.70 (m, 8H), 8.25-8.35 (m, 2H), 8.55 (d, J=6.0 Hz, 2H); LC retention time 3.86 min; MS: m/z (ESI) 415 (M−H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07423044B2
出典データセットuspto-grants-2008_09
ORD IDord-91b7c6a3183541e5a89476a26877f28d
出典メモuspto-grants-2008_09