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HRID 29911作成日：2026年10月25日

1-(Bromomethyl)-4-(trifluoromethyl)benzene → 6-Benzyl-2-(3,5-dichlorophenyl)-4-{[4-(trifluoromethyl)benzyl]oxy}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidine

https://huagongshe.com/reaction/29911

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 123062—
反応物HCID 178517513HCID 178517513—
生成物6-Benzyl-2-(3,5-dichlorophenyl)-4-{[4-(trifluoromethyl)benzyl]oxy}-5,6,7,8-tetrahydropyrido[4,3-d]pyrimidineHCID 69198134—

反応手順

The title compound was prepared from 6-benzyl-2-(3,5-dichloro-phenyl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-ol (which was obtained in Intermediate 7) and 4-(trifluoromethyl)benzyl bromide according to Method A; LC retention time 3.49 min; MS: m/z (ESI) 544 (M+H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07423044B2
出典データセットuspto-grants-2008_09
ORD IDord-e6f15f64472c4ca78d6d8284e09f210f
出典メモuspto-grants-2008_09