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HRID 29912作成日：2026年10月25日

1-(Bromomethyl)-4-(trifluoromethyl)benzene → 4-Isopropyl-2-(3-nitrophenyl)-6-{[4-(trifluoromethyl)benzyl]oxy} pyrimidine

https://huagongshe.com/reaction/29912

反応式

関与物質

役割名称HCID仕込み量
反応物1-(Bromomethyl)-4-(trifluoromethyl)benzeneHCID 123062—
反応物HCID 178439455HCID 178439455—
生成物4-Isopropyl-2-(3-nitrophenyl)-6-{[4-(trifluoromethyl)benzyl]oxy} pyrimidineHCID 10070573—

反応手順

The title compound was prepared from 6-isopropyl-2-(3-nitro-phenyl)-pyrimidin-4-ol (which was obtained in Intermediate 8) and 4-(trifluoromethyl)benzyl bromide according to Method A; 1H NMR (DMSO-d6, 300 MHz) δ 1.30 (d, J=6.8 Hz, 6H), 3.00-3.10 (m, 1H), 5.69 (s, 2H), 6.95 (s, 1H), 7.75-7.85 (m, 4H), 7.84 (t, J=8.1 Hz, 1H), 8.38 (t, J=8.1 Hz, 1H), 8.80 (d, J=7.8 Hz, 1H), 9.08 (s, 1H); LC retention 4.18 min; MS: m/z (ESI) 418 (M+H).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07423044B2
出典データセットuspto-grants-2008_09
ORD IDord-fd1604433a7142f08720bc7c6537dbf9
出典メモuspto-grants-2008_09