2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(methoxyacetyl)benzoic acid

反応式

Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.[CH3:18][O:19][CH2:20][C:21](N(OC)C)=[O:22]>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([C:21](=[O:22])[CH2:20][O:19][CH3:18])=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

参加物

反応物 3

HCID 899062-Bromo-5-methoxybenzoic acid

HCID 14872187N,2-dimethoxy-N-methylacetamide

HCID 178418339Butyllithium

生成物 1

HCID 576916415-Methoxy-2-(methoxyacetyl)benzoic acid

実験手順

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with 2,N-dimethoxy-N-methylacetamide. It is used in crude form in the following reaction.