2-Bromo-5-methoxybenzoic acid → 5-Methoxy-2-(4-methoxymethylbenzoyl)benzoic acid

反応式

Br[C:2]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].C([Li])CCC.CON(C)[C:21](=[O:31])[C:22]1[CH:27]=[CH:26][C:25]([CH2:28][O:29][CH3:30])=[CH:24][CH:23]=1>>[CH3:12][O:11][C:8]1[CH:9]=[CH:10][C:2]([C:21](=[O:31])[C:22]2[CH:23]=[CH:24][C:25]([CH2:28][O:29][CH3:30])=[CH:26][CH:27]=2)=[C:3]([CH:7]=1)[C:4]([OH:6])=[O:5]

参加物

反応物 3

HCID 899062-Bromo-5-methoxybenzoic acid

HCID 60645894n-Methoxy-4-methoxymethyl-n-methylbenzamide

HCID 178418339Butyllithium

生成物 1

HCID 692142505-Methoxy-2-(4-methoxymethylbenzoyl)benzoic acid

実験手順

This compound is synthesized according to the method described in 3.2. by reacting 2-bromo-5-methoxybenzoic acid pretreated with n-butyllithium with N-methoxy-4-methoxymethyl-N-methylbenzamide. The product is crystallized from diisopropyl ether.