Ammonia → HCID 178424203、化合物

HRID 30088

反応式

HRID 30088 の反応式
[NH2:1][CH2:2][CH2:3][NH:4][C:5]1[N:6]=[C:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[C:8]2[CH:14]=[CH:13][C:12](=[O:15])[N:11]([C:16]3[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=3[F:23])[C:9]=2[N:10]=1.C1C=CC(O[C:38](OC2C=CC=CC=2)=[N:39][C:40]#[N:41])=CC=1.[NH3:49]>C(O)(C)C>[C:38]([NH:39][C:40]([NH:1][CH2:2][CH2:3][NH:4][C:5]1[N:6]=[C:7]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][C:25]=2[CH3:30])[C:8]2[CH:14]=[CH:13][C:12](=[O:15])[N:11]([C:16]3[C:21]([F:22])=[CH:20][CH:19]=[CH:18][C:17]=3[F:23])[C:9]=2[N:10]=1)=[NH:41])#[N:49]

参加物

5

反応物 3

HCID 222AmmoniaHCID 688090Diphenyl N-CyanocarbonimidateHCID 597893312-[(2-aminoethyl)amino]-8-(2,6-difluorophenyl)-4-(2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one

生成物 1

HCID 178424203HCID 178424203、化合物収率 59%

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒2 回

反応条件

温度
20 °C

実験手順

To a solution of 2-[(2-aminoethyl)amino]-8-(2,6-difluorophenyl)-4-(2-methylphenyl)pyrido[2,3-d]pyrimidin-7(8H)-one (20 mg, 0.050 mmol) in isopropanol (2 mL) was added diphenyl cyanocarbonimidate (12 mg, 0.050 mmol) and the mixture was stirred for about 1 hour at about 20° C. A 2M solution of ammonia in isopropanol (2 ml) was added and the mixture stirred at about 20° C. for about 3 days. The solvent was evaporated and the residue redissolved in 2M ammonia in isopropanol (2 mL). The mixture was irradiated with microwave at about 60° C. for about 40 min. The mixture was stored in a sealed tube for 7 days. The solvent was evaporated and the crude product was purified to give the title compound (14 mg, 59%). LC-MS m/z 475 (M+H)+, 2.93 min (ret time).

後処理

  1. stirringthe mixture stirred at about 20° C. for about 3 days
  2. customThe solvent was evaporated
  3. dissolutionthe residue redissolved in 2M ammonia in isopropanol (2 mL)
  4. customThe mixture was irradiated with microwave at about 60° C. for about 40 min
  5. waitThe mixture was stored in a sealed tube for 7 days
  6. customThe solvent was evaporated
  7. customthe crude product was purified

出典と根拠

ORDレコード
ord-d6d72ef944a94ccd906ad61c9f8f0559
出典データセット
uspto-grants-2008_09
特許番号
US07423042B2

関連ノート

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