Ammonium Hydroxide → 2-Amino-6-chloronicotinic acid

HRID 30096

反応式

HRID 30096 の反応式
Cl[C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[OH-].[NH4+:13]>>[NH2:13][C:2]1[N:10]=[C:9]([Cl:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

参加物

3

反応物 2

HCID 14923Ammonium HydroxideHCID 8540472,6-Dichloronicotinic acid

生成物 1

HCID 122639922-Amino-6-chloronicotinic acid収率 34%

反応条件

温度
145 °C

実験手順

A solution of 2,6-dichloronicotinic acid (10 g, 46.9 mmol, Aldrich 90%) was dissolved in concentrated ammonium hydroxide (100 mL, 29.4%, Fisher) and heated at 130-160° C. in a pressure bottle for 1-2 days before solvent was removed in vacuo. The residue was treated with water and the pH was lowered to ˜8 with concentrated hydrochloric acid. The resulting mixture was extracted with ethyl acetate and the combined organic extracts were washed with brine, dried, concentrated and the crude product was recrystallized from ethyl acetate to give 2-Amino-6-chloro-nicotinic acid as white crystalline (2.74g, 34 % yield). HRMS, observed: 172.0042, Calcd for M+: 172.0040

後処理

  1. customwas removed in vacuo
  2. additionThe residue was treated with water
  3. extractionThe resulting mixture was extracted with ethyl acetate
  4. washthe combined organic extracts were washed with brine
  5. customdried
  6. concentrationconcentrated
  7. customthe crude product was recrystallized from ethyl acetate

出典と根拠

ORDレコード
ord-6237c299266048aca0b33d6d74d4643e
出典データセット
uspto-grants-2008_09
特許番号
US07423051B2

関連ノート

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