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HRID 30125作成日：2026年10月25日

Propyl chloroformate → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid propyl ester

https://huagongshe.com/reaction/30125

反応式

関与物質

役割名称HCID仕込み量
反応物Propyl chloroformateHCID 7998—
反応物[4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid saltHCID 21070627—
生成物4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid propyl esterHCID 11711671—

反応手順

The title compound was prepared from [4-amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and 1-propyl chloroformate (Aldrich 98%) using the procedure described in Example 24. HRMS, observed: 431.2095, Calcd for (M+H)+: 431.2089.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07423051B2
出典データセットuspto-grants-2008_09
ORD IDord-c0687cd1d52d4fe6a285679a6f20e484
出典メモuspto-grants-2008_09