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Methyl Isocyanate → 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Methyl Isocyanate | HCID 12228 | — |
| 反応物 | [4-Amino-2-(piperidin4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt | HCID 21070627 | — |
| 生成物 | 4-[6-Amino-5-(5-fluoro-2-methoxy-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid methylamide | HCID 11545824 | — |
反応手順
The title compound was prepared from [4-amino-2-(piperidin-4-ylamino)-pyrimidin-5-yl]-(5-fluoro-2-methoxy-phenyl)-methanone trifluoroacetic acid salt (Example 22) and methyl isocyanate (Aldrich, 98%) using the procedure described in Example 24. HRMS, observed: 402.1940, Calcd for (M+H)+: 402.1936.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423051B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-679e22877aea40898d3601f9b5da6384 |
| 出典メモ | uspto-grants-2008_09 |