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HRID 30142作成日：2026年10月26日

[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone

https://huagongshe.com/reaction/30142

反応式

関与物質

役割名称HCID仕込み量
反応物[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 11975076—
反応物(2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanoneHCID 58590831—
生成物[2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanoneHCID 11669262—

反応手順

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 43) and 1-methanesulfonyl-piperidin-4-ylamine (Step A, Example 6) using the procedure described in Step B. Example 6. HRMS, observed 437.1653, Calcd for (M+H)+: 437.1654.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07423051B2
出典データセットuspto-grants-2008_09
ORD IDord-563ca61d07894ce6b1c970640de235b0
出典メモuspto-grants-2008_09