Ethyl 4-amino-1-piperidinecarboxylate → 4-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester

HRID 30143

反応式

HRID 30143 の反応式
[NH2:1][C:2]1[C:7]([C:8]([C:10]2[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=2[O:18][CH3:19])=[O:9])=[CH:6][CH:5]=[C:4](Cl)[N:3]=1.[CH2:21]([O:23][C:24]([N:26]1[CH2:31][CH2:30][CH:29]([NH2:32])[CH2:28][CH2:27]1)=[O:25])[CH3:22]>>[CH2:21]([O:23][C:24]([N:26]1[CH2:27][CH2:28][CH:29]([NH:32][C:4]2[CH:5]=[CH:6][C:7]([C:8](=[O:9])[C:10]3[CH:15]=[C:14]([F:16])[C:13]([CH3:17])=[CH:12][C:11]=3[O:18][CH3:19])=[C:2]([NH2:1])[N:3]=2)[CH2:30][CH2:31]1)=[O:25])[CH3:22]

参加物

3

反応物 2

HCID 100867Ethyl 4-amino-1-piperidinecarboxylateHCID 58590831(2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone

生成物 1

HCID 115247924-[6-Amino-5-(5-fluoro-2-methoxy-4-methyl-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester

実験手順

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(5-fluoro-2-methoxy-4-methyl-phenyl)-methanone (Example 43) and ethyl-4-amino- 1-piperidine carboxylate (Aldrich 96%) using the procedure described in Step B. Example 6. HRMS, observed: 431.2090, Calcd for (M+H)+: 431.2089.

出典と根拠

ORDレコード
ord-06dfe7381dc5433d95e2da75f0c5647d
出典データセット
uspto-grants-2008_09
特許番号
US07423051B2

関連ノート

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