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HRID 30146作成日：2026年10月25日

[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetate → [2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone

https://huagongshe.com/reaction/30146

反応式

関与物質

役割名称HCID仕込み量
反応物[1-(Methylsulfonyl)piperidin-4-yl]amine trifluoroacetateHCID 11975076—
反応物(2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanoneHCID 58590823—
生成物[2-Amino-6-(1-methanesulfonyl-piperidin-4-ylamino)-pyridin-3-yl]-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanoneHCID 11705192—

反応手順

The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone (Example 47) and 1-methanesulfonyl-piperidin-4-ylamine (Step A, Example 6) using the procedure described in Step B. Example 6. HRMS, observed: 457.1106, Calcd for (M+H)+: 457.1107. Ki for cdk4=0.008 μM, cdk1=0.154 μM, cdk2=0.039 μM, and IC50 for HCT116 cell line=3.0 μM.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07423051B2
出典データセットuspto-grants-2008_09
ORD IDord-8be0577ea87f4689af3358b7a02cb424
出典メモuspto-grants-2008_09