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Ethyl 4-amino-1-piperidinecarboxylate → 4-[6-Amino-5-(5-fluoro-2-methoxy-4-chloro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethyl 4-amino-1-piperidinecarboxylate | HCID 100867 | — |
| 反応物 | (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone | HCID 58590823 | — |
| 生成物 | 4-[6-Amino-5-(5-fluoro-2-methoxy-4-chloro-benzoyl)-pyridin-2-ylamino]-piperidine-1-carboxylic acid ethyl ester | HCID 11554211 | — |
反応手順
The title compound was prepared from (2-Amino-6-chloro-pyridin-3-yl)-(4-chloro-5-fluoro-2-methoxy-phenyl)-methanone (Example 47) and ethyl4-amino-1-piperidine carboxylate (Aldrich 96%) using the procedure described in Step B. Example 6. HRMS, observed: 451.1545, Calcd for (M+H)+: 451.1543.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423051B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-d662b7b1e994447ab29f72792bedc7fd |
| 出典メモ | uspto-grants-2008_09 |