3-Fluoroacetophenone → 3-Fluorophenacyl bromide

HRID 30153ノート

反応式

HRID 30153 の反応式
[F:1][C:2]1[CH:3]=[C:4]([C:8](=[O:10])[CH3:9])[CH:5]=[CH:6][CH:7]=1.[Br:11]Br>O1CCOCC1>[Br:11][CH2:9][C:8]([C:4]1[CH:5]=[CH:6][CH:7]=[C:2]([F:1])[CH:3]=1)=[O:10]

参加物

4

反応物 2

HCID 99673-FluoroacetophenoneHCID 24408Bromine

生成物 1

HCID 27374513-Fluorophenacyl bromide

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of 1-(3-fluorophenyl)ethanone (14.0 g, 100 mmol) (Aldrich) in dioxane (250 mL) at 12-15° C. was treated with a solution of bromine (17 g, 105 mmol) in dioxane (120 mL) drop wise over 0.5 h. This was stirred for 15 min and most of the solvent removed. The residue was taken up in hexane (200 mL), washed 2× water, and dried (MgSO4). Solvent was removed to give 2-bromo-1-(3-fluorophenyl)ethanone. 1H NMR (CDCl3), 300 MHz) δ3.71 (s, 2H, CH2), 7.30-7.77(m, 4H, Aromatic).

後処理

  1. customremoved
  2. washwashed 2× water
  3. dry with materialdried (MgSO4)
  4. customSolvent was removed

出典と根拠

ORDレコード
ord-b5a4959aa8414c598e9a19d8cf9c0e80
出典データセット
uspto-grants-2008_09
特許番号
US07423053B2

反応ノート

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