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Trifluoroacetic acid → (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Trifluoroacetic acid | HCID 6422 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester | HCID 86628996 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine | HCID 67157689 | 92.8% |
反応手順
A solution of (RS)-2-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester (0.175 g) in dichloromethane (4 ml) was cooled (ice bath) and treated with trifluoroacetic acid (1 ml). The mixture was stirred for 1 h, added to saturated potassium carbonate and the product extracted into dichloromethane. The organic phase was dried (MgSO4) and solvent removed at reduced pressure to give the title compound (0.115 g)
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423052B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-85980ce2c0e5457c8f73a7bbffbec9e7 |
| 出典メモ | uspto-grants-2008_09 |