Trifluoroacetic acid → (RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine

HRID 30164

反応式

HRID 30164 の反応式
C(OC([N:8]1[CH2:13][CH2:12][CH2:11][CH2:10][CH:9]1[CH2:14][C:15]1[O:16][C:17]([C:20]2[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=2)=[N:18][N:19]=1)=O)(C)(C)C.FC(F)(F)C(O)=O.C(=O)([O-])[O-].[K+].[K+]>ClCCl>[C:20]1([C:17]2[O:16][C:15]([CH2:14][CH:9]3[CH2:10][CH2:11][CH2:12][CH2:13][NH:8]3)=[N:19][N:18]=2)[CH:21]=[CH:22][CH:23]=[CH:24][CH:25]=1

参加物

5

反応物 3

HCID 6422Trifluoroacetic acidHCID 11430Potassium CarbonateHCID 86628996(RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester

生成物 1

HCID 67157689(RS)-2-(5-Phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine収率 92.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of (RS)-2-(5-phenyl-[1,3,4]oxadiazol-2-ylmethyl)-piperidine-1-carboxylic acid tert butyl ester (0.175 g) in dichloromethane (4 ml) was cooled (ice bath) and treated with trifluoroacetic acid (1 ml). The mixture was stirred for 1 h, added to saturated potassium carbonate and the product extracted into dichloromethane. The organic phase was dried (MgSO4) and solvent removed at reduced pressure to give the title compound (0.115 g)

後処理

  1. extractionthe product extracted into dichloromethane
  2. dry with materialThe organic phase was dried (MgSO4) and solvent
  3. customremoved at reduced pressure

出典と根拠

ORDレコード
ord-85980ce2c0e5457c8f73a7bbffbec9e7
出典データセット
uspto-grants-2008_09
特許番号
US07423052B2

関連ノート

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