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HRID 3028作成日：2026年10月23日

Pyridine, hydrofluoride (1:1) → methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate

https://huagongshe.com/ja/reaction/3028

反応式

関与物質

役割名称HCID仕込み量
反応物Pyridine, hydrofluoride (1:1)HCID 64774—
反応物methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoateHCID 22883798—
生成物methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoateHCID 2288379964%

反応手順

Using as the material and reagent a hydrogen fluoride-pyridine solution (0.6 ml) and methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoate (466 mg), the same procedure as in Example 2 was performed to obtain methyl(11R,12S,13E,15S,17R)-9-isobutyryloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate (192 mg, 64%).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05731452
出典データセットuspto-grants-1998_03
ORD IDord-e25048cd0b1a4d4a97c39af9be62f679
出典メモuspto-grants-1998_03