HCID 67205102、化合物 → 1-(1-Phenyl-ethyl)-4-thiophen-2-yl-pyrrolidine-3-carboxylic acid

HRID 30290ノート

反応式

HRID 30290 の反応式
C([O:3][C:4]([CH:6]1[CH:10]([C:11]2[S:12][CH:13]=[CH:14][CH:15]=2)[CH2:9][N:8]([CH:16]([C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=2)[CH3:17])[CH2:7]1)=[O:5])C.C1NCC2C1CC1C(C#N)=CSC=12>>[C:18]1([CH:16]([N:8]2[CH2:9][CH:10]([C:11]3[S:12][CH:13]=[CH:14][CH:15]=3)[CH:6]([C:4]([OH:5])=[O:3])[CH2:7]2)[CH3:17])[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=1

参加物

3

反応物 2

HCID 67205102HCID 67205102、化合物HCID 683017591,2,3,3a,7,7a-Hexahydro-4-thia-2-aza-cyclopenta[alpha]pentalene-6-carbonitrile

生成物 1

HCID 672065311-(1-Phenyl-ethyl)-4-thiophen-2-yl-pyrrolidine-3-carboxylic acid

実験手順

The product from step b), diastereomer 1 (5.8 g, 0.019 mol) was treated by the method outlined in Example 34, step c) to afford the subtitle compound that was used in the next step without further purification. MS calculated for C17H19NO2S+H: 302, observed: 302.

出典と根拠

ORDレコード
ord-5e42c6e129114414b4600fbd19814175
出典データセット
uspto-grants-2008_09
特許番号
US07423056B2

反応ノート

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