4-Bromothiophene-2-carbaldehyde → 3-(4-Bromo-thiophen-2-yl)-acrylic acid methyl ester

HRID 30291

反応式

HRID 30291 の反応式
[Br:1][C:2]1[CH:3]=[C:4]([CH:7]=O)[S:5][CH:6]=1.[CH3:9][O:10][C:11](=[O:27])[CH2:12]P(OCC(F)(F)F)(OCC(F)(F)F)=O>>[CH3:9][O:10][C:11](=[O:27])[CH:12]=[CH:7][C:4]1[S:5][CH:6]=[C:2]([Br:1])[CH:3]=1

参加物

3

反応物 2

HCID 877924-Bromothiophene-2-carbaldehydeHCID 184894Nsc 634137

生成物 1

HCID 541625193-(4-Bromo-thiophen-2-yl)-acrylic acid methyl ester収率 78%

実験手順

4-Bromo-thiophene-2-carbaldehyde (44 g, 0.23 mol) and [Bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic methyl ester (80.6 g, 0.253 mol) were treated by the method outlined in Example 34, step a) to afford the subtitle compound that was purified by column chromatography (SiO2) using a 0-60% ethylacetate-hexane gradient (46.22 g, yield: 78%). MS calculated for C8H7BrO2S+H: 247, observed: 247 249.

出典と根拠

ORDレコード
ord-f2db750a4b23425ba000baac5c129435
出典データセット
uspto-grants-2008_09
特許番号
US07423056B2

関連ノート

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