2-Thiophenecarboxaldehyde → Methyl 3-(thiophen-2-yl)acrylate

反応式

[S:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH:6]=O.[CH3:8][O:9][C:10](=[O:26])[CH2:11]P(OCC(F)(F)F)(OCC(F)(F)F)=O>>[CH3:8][O:9][C:10](=[O:26])[CH:11]=[CH:6][C:2]1[S:1][CH:5]=[CH:4][CH:3]=1

参加物

反応物 2

HCID 73642-Thiophenecarboxaldehyde

HCID 184894Nsc 634137

生成物 1

HCID 2778970Methyl 3-(thiophen-2-yl)acrylate収率 75%

実験手順

Thiophene-2-carbaldehyde (4.00 g, 35.7 mmol) and [bis-(2,2,2-trifluoro-ethoxy)-phosphoryl]-acetic acid methyl ester (12.5 g, 39.3 mmol) were treated by the method outlined in Example 34, step a to afford the subtitle compound (4.5 g, yield: 75%). MS calculated for C8H8O2S+H: 169, observed: 169.

出典と根拠

ORDレコード: ord-af0c01bc0e364401b9be3bda4a583535
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07423056B2

反応ノート

読み込み中…