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HRID 3034作成日：2026年10月24日

Pyridine, hydrofluoride (1:1) → methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate

https://huagongshe.com/ja/reaction/3034

反応式

関与物質

役割名称HCID仕込み量
反応物Pyridine, hydrofluoride (1:1)HCID 64774—
反応物methyl (11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoateHCID 22883791—
生成物methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoateHCID 2288379228%

反応手順

Using as the material and reagent a hydrogen fluoride-pyridine solution (0.7 ml) and methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-bis(tert-butyldimethylsiloxy)-17,20-dimethyl-7-thiaprosta-8,13-dienoate (734 mg), the same procedure as in Example 2 was performed to obtain methyl(11R,12S,13E,15S,17R)-9-benzoyloxy-11,15-dihydroxy-17,20-dimethyl-7-thiaprosta-8,13-dienoate (141 mg, 28%)

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05731452
出典データセットuspto-grants-1998_03
ORD IDord-22a46d06c9484f61abcb3ba9fcd4507b
出典メモuspto-grants-1998_03