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HRID 3035作成日：2026年10月24日

Pyridine, hydrofluoride (1:1) → methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-dihydroxy-7-thiaprosta-8,13-dienoate

https://huagongshe.com/ja/reaction/3035

反応式

関与物質

役割名称HCID仕込み量
反応物Pyridine, hydrofluoride (1:1)HCID 64774—
反応物methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienoateHCID 22883810—
生成物methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-dihydroxy-7-thiaprosta-8,13-dienoateHCID 2288381151%

反応手順

Using as the material and reagent a hydrogen fluoride-pyridine solution (0.3 ml) and methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-bis(tert-butyldimethylsiloxy)-7-thiaprosta-8,13-dienoate (140 mg), methyl(11R,12S,13E,15S)-9-(N-benzyloxycarbonylphenylalanyloxy)-11,15-dihydroxy-7-thiaprosta-8,13-dienoate (53 mg, 51%) was obtained.

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US05731452
出典データセットuspto-grants-1998_03
ORD IDord-d5c0f98feabe41e293e98aa397fcf97a
出典メモuspto-grants-1998_03