Cyclobutanecarboxylate → 1-(1,1-Dimethylethyl) 3-ethyl-1,3-azetidinedicarboxylate

反応式

[CH:1]1([C:5]([O-:7])=[O:6])[CH2:4][CH2:3][CH2:2]1.[C:8]([O:12][C:13]([N:15]1CC(C(OC)=O)[CH2:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9]>>[C:8]([O:12][C:13]([N:15]1[CH2:4][C:1]([CH2:2][CH3:3])([C:5]([OH:7])=[O:6])[CH2:16]1)=[O:14])([CH3:11])([CH3:10])[CH3:9]

参加物

反応物 2

HCID 6993960Cyclobutanecarboxylate

HCID 446076271-tert-Butyl 3-methyl azetidine-1,3-dicarboxylate

生成物 1

HCID 450957291-(1,1-Dimethylethyl) 3-ethyl-1,3-azetidinedicarboxylate

実験手順

The title compound was prepared following the procedure described for Reference Example 10 substituting cyclobutanecarboxylate with methyl 1-tert-butoxycarbonylazetidine-3-carboxylate. 1H NMR (500 MHz, CD3OD): δ 4.12 (d, 2H), 3.70 (d, 2H), 1.82 (q, 2H), 1.42 (s, 9H), 0.90 (t, 3H).

出典と根拠

ORDレコード: ord-47503c6217e74a16944ee6d4b199ec7f
出典データセット: uspto-grants-2008_09
DOI: 10.6084/m9.figshare.5104873.v1
特許番号: US07423067B2

反応ノート

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