8-Amino-1,3,4,5-tetrahydro-2H-1-benzazepin-2-one → 8-{5-Chloro-4-[2-fluoro-6-(tetrahydro-pyran-4-yloxy)-phenylamino]-pyrimidin-2-ylamino}-1,3,4,5-tetrahydro-1-benzazepin-2-one

HRID 303753

反応式

[Cl:14][c:15]1[n:16][cH:17][c:18]([Cl:36])[c:19]([NH:21][c:22]2[c:23]([F:35])[cH:24][cH:25][cH:26][c:27]2[O:28][CH:29]2[CH2:30][CH2:31][O:32][CH2:33][CH2:34]2)[n:20]1.[NH2:1][c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2>>[NH:1]([c:2]1[cH:3][cH:4][c:5]2[c:6]([cH:13]1)[NH:7][C:8](=[O:12])[CH2:9][CH2:10][CH2:11]2)[c:15]1[n:16][cH:17][c:18]([Cl:36])[c:19]([NH:21][c:22]2[c:23]([F:35])[cH:24][cH:25][cH:26][c:27]2[O:28][CH:29]2[CH2:30][CH2:31][O:32][CH2:33][CH2:34]2)[n:20]1