Bromine → [2-(Bromoethyl)-6-(3-methoxyphenyl)pyrimidin-4-yl]-3-pyridylamine

反応式

[CH2:1]([C:3]1[N:8]=[C:7]([NH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:6]=[C:5]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)[N:4]=1)[CH3:2].C([O-])(=O)C.[Na+].[Br:29]Br>C(O)(=O)C>[Br:29][CH2:2][CH2:1][C:3]1[N:8]=[C:7]([NH:9][C:10]2[CH:11]=[N:12][CH:13]=[CH:14][CH:15]=2)[CH:6]=[C:5]([C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][CH3:23])[CH:17]=2)[N:4]=1

参加物

実験手順

[2-ethyl-6-(3-methoxyphenyl)pyrimidin-4-yl]-3-pyridylamine 14 (synthesized with a procedure similar to the one previously described) (1 eq) is dissolved in acetic acid, then sodium acetate (2 eq) is added. To this mixture, a solution of bromine (1 eq) in acetic acid is added dropwise. The reaction is stirred at room temperature for 3 h. The reaction mixture is concentrated under reduced pressure, water is added and the solution basified (pH ˜10-11) with sat. aq. Na2CO3 solution. The product 15 crashes out, is filtered off, dried, and used as is in the following step.