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Diethyl Malonate → HCID 178418389、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diethyl Malonate | HCID 7761 | — |
| 反応物 | Acetamidine monohydrochloride | HCID 67170 | — |
| 反応物 | Sodium ethoxide | HCID 2723922 | — |
| 反応物 | Sodium | HCID 5360545 | — |
| 反応物 | 4,6-Dihydroxy-2-methylpyrimidinamine | HCID 178418345 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | HCID 178418389 | HCID 178418389 | — |
反応手順
The first intermediate, 4,6-dihydroxy-2-methylpyrimidinamine, is synthesized by preparing sodium ethoxide in situ from sodium and an hydrous ethanol under a nitrogen blanket. Acetamidine hydrochloride and diethyl malonate are added and the reaction mixture heated to boiling for 2 to 5 hours to afford 4,6-dihydroxy-2-methylpyrimidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05732717 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-4d14267579d347aaab5da8765031fa8d |
| 出典メモ | uspto-grants-1998_03 |