化工社化工社 化学情報印刷レポート · 研究参考用
4,6-Dichloro-2-methyl-5-nitropyrimidine → 4,6-Dichloro-2-methylpyrimidin-5-amine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4,6-Dichloro-2-methyl-5-nitropyrimidine | HCID 83192 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 4,6-Dichloro-2-methylpyrimidin-5-amine | HCID 736674 | — |
反応手順
The third intermediate, 4,6-dichloro-2-methyl-5-nitropyrimidine is hydrogenated over Raney-Ni as a 10% to 30% solution in toluene to afford the corresponding compound, 4,6-dichloro-2-methyl-5-aminopyrimidine, as a fourth intermediate.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05732717 |
| 出典データセット | uspto-grants-1998_03 |
| ORD ID | ord-fc482eaeb84f48f6beade7036825e8ec |
| 出典メモ | uspto-grants-1998_03 |