Piperidine → 2-Bromo-6-piperidin-1-ylmethylpyridine
反応式
[Br:1][C:2]1[N:7]=[C:6]([CH:8]=O)[CH:5]=[CH:4][CH:3]=1.[NH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1>>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]([CH2:8][N:10]2[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[N:7]=1参加物
3
実験手順
The title compound was prepared in a manner similar to that described in Example 18, Step C, using 6-bromo-pyridine-2-carbaldehyde (0.406 g, 2.18 mmol) and piperidine (0.186 g, 2.18 mmol). The crude product was purified (SiO2: 0-4% 2 M NH3 in MeOH/DCM) to provide the title compound (0.46 g, 83%).
後処理
- customThe title compound was prepared in a manner similar to
- customThe crude product was purified (SiO2: 0-4% 2 M NH3 in MeOH/DCM)
出典と根拠
- ORDレコード
- ord-80147ff5faa744f38515986596c0a938
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07423147B2
反応ノート
読み込み中…