化工社化工社 化学情報印刷レポート · 研究参考用
N,N,N',N',N'',N''-Hexamethylmethanetriamine → (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N,N,N',N',N'',N''-Hexamethylmethanetriamine | HCID 79831 | — |
| 反応物 | 2-oxo-butyric acid (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenyl-ethyl)-cyclohexyl ester | HCID 11088396 | — |
| 反応物 | (S)-5-diethylcarbamoyl-5-ethyl-4-methyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11687992 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | (S)-5-diethylcarbamoyl-4-((E)-2-dimethylamino-vinyl)-5-ethyl-2-oxo-2,5-dihydro-furan-3-carboxylic acid ethyl ester | HCID 11523197 | — |
反応手順
According to the procedure described in Example 6 1.22 0 g of compound (23) as obtained from example 17 (4.103 mmol) in 7.3 mL dimethyl formamide were treated with 7.55 mL tris(dimethylamino)methane (42.26 mmol, 10.3 eq) yielding the crude product as an orange oil (1.463 mg, 101% by weight).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423152B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-bbd7d798654d40d2a16d1a5d7de0ddf3 |
| 出典メモ | uspto-grants-2008_09 |