関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 2-hydrazinyl-1H-1,3-benzodiazole | HCID 95788 | — |
| 反応物 | Methanimidic acid, N-cyano-, ethyl ester | HCID 9920370 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 2-(1H-Benzoimidazol-2-YL)-2H-[1,2,4]triazol-3-ylamine | HCID 608264 | — |
反応手順
To a solution of 2-hydrazino-1H-benzimidazole (5.0 g, 33.7 mmol) in ethanol (30 ml) is added sequentially triethylamine (5 ml, 33.7 mmol) and N-cyanoformimidic acid ethyl ester (3.3 g, 33.7 mmol) with cooling. After stirring for 2 hours at 0° C. the resulting precipitate is filtered with suction and dried to give 3-amino-2-(1H-benzimidazol-2-yl)-1,2,4-triazole. 1H-NMR (400 MHz, d6-DMSO): 13.0 (s, 1H); 7.77 (s,1H); 7.70 (m, 2H); 7.50 (m, 2H); 7.20 (s, 2H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US07423157B2 |
|---|
| 出典データセット | uspto-grants-2008_09 |
|---|
| ORD ID | ord-7f10adc0d7e24d279472728a0b3b4fc5 |
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| 出典メモ | uspto-grants-2008_09 |
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