Bromomethyl 4-methoxyphenyl ketone → 5-Amino-2-(1-[4-methoxyphenylcarbonylmethyl]benzimidazol-2-yl)-pyrazole

HRID 30506

反応式

HRID 30506 の反応式
[NH2:1][C:2]1[CH:3]=[CH:4][N:5]([C:7]2[NH:11][C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[N:6]=1.[CH3:16][O:17][C:18]1[CH:27]=[CH:26][C:21]([C:22](=[O:25])[CH2:23]Br)=[CH:20][CH:19]=1.C(=O)([O-])[O-].[K+].[K+]>O>[NH2:1][C:2]1[CH:3]=[CH:4][N:5]([C:7]2[N:11]([CH2:23][C:22]([C:21]3[CH:26]=[CH:27][C:18]([O:17][CH3:16])=[CH:19][CH:20]=3)=[O:25])[C:10]3[CH:12]=[CH:13][CH:14]=[CH:15][C:9]=3[N:8]=2)[N:6]=1

参加物

5

反応物 3

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 11430Potassium CarbonateHCID 574644725-amino-2-(1H-benzimidazol-2-yl)pyrazole

生成物 1

HCID 574943345-Amino-2-(1-[4-methoxyphenylcarbonylmethyl]benzimidazol-2-yl)-pyrazole

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

A suspension of 5-amino-2-(1H-benzimidazol-2-yl)pyrazole (0.10 g, 0.5 mmol), p-methoxyphenacyl bromide (0.204 g, 0.9 mmol) and dry potassium carbonate (0.173 g, 1.25 mmol) is stirred at room temperature for 16 hours. The mixture is diluted with water and the product extracted with ethyl acetate. The product is purified by chromatography on silicagel. M.p. 136-140° C., 1H-NMR (400 MHz, d6-DMSO): 8.04 (d, 2H); 7.58 (m, 2H); 7.28 (m, 3H); 7.11 (d, 2H); 6.84 (s, 2H); 6.26 (s, 2H); 5.39 (d, 1H); 3.87 (s, 3H).

後処理

  1. extractionthe product extracted with ethyl acetate
  2. customThe product is purified by chromatography on silicagel

出典と根拠

ORDレコード
ord-f8b0f03890c64aedba67ef2fd6510344
出典データセット
uspto-grants-2008_09
特許番号
US07423157B2

関連ノート

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