Hydrochloric Acid → Ethanamine, 2-(4-fluorophenoxy)-, hydrochloride (1:1)

HRID 30537

反応式

HRID 30537 の反応式
C(OC(=O)[NH:7][CH2:8][CH2:9][O:10][C:11]1[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=1)(C)(C)C.[ClH:19]>O1CCOCC1>[ClH:19].[F:17][C:14]1[CH:15]=[CH:16][C:11]([O:10][CH2:9][CH2:8][NH2:7])=[CH:12][CH:13]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 23134036(2-(4-Fluorophenoxy)-ethyl)-carbamic acid tert-butyl ester

生成物 1

HCID 22061356Ethanamine, 2-(4-fluorophenoxy)-, hydrochloride (1:1)収率 80.7%

試薬・触媒・溶媒 1

HCID 312751,4-Dioxane溶媒2 回

反応条件

温度
0 °C

実験手順

Next, to a solution of [2-(4-fluorophenoxy)ethyl]carbamic acid tert-butyl ester (7.0 g, 27.4 mmol) in dioxane (20 mL) cooled in an ice bath was added 4N—HCl in dioxane (100 mL) dropwise. The mixture was stirred at 0° C. for 2 hours, and at room temperature for 16 hours. The precipitates were filtered, washed with diethylether, and dried under reduced pressure to yield 2-(4-fluorophenoxy)ethylamine HCl salt (4.24 g, 80.7% yield).

後処理

  1. waitat room temperature for 16 hours
  2. filtrationThe precipitates were filtered
  3. washwashed with diethylether
  4. customdried under reduced pressure

出典と根拠

ORDレコード
ord-54903767278b4fbbaa8fd42caec3bb42
出典データセット
uspto-grants-2008_09
特許番号
US07423175B2

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