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Potassium Carbonate → 3-(N,N-diethylaminopropoxy)butyranilide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | Butyranilide, 3'-hydroxy- | HCID 30688 | — |
| 反応物 | Methanesulfonate | HCID 85257 | — |
| 反応物 | Diethylamino-propanol | HCID 5256659 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-(N,N-diethylaminopropoxy)butyranilide | HCID 68428240 | 88.9% |
反応手順
The mesylate of N,N-diethylaminopropanol (6 mmol), prepared as described in Example 18 above, was mixed with 3-butyramidophenol (5.0 mmol), and K2CO3 (10 mmol) in anhydrous DMF (10 mL) and the reaction is performed following general procedure B. The crude product is purified using silica gel column chromatography 5% MeOH/DCM as eluent to yield 3-(N,N-diethylaminopropoxy)butyranilide (1.3 g).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423177B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-67fb278fb8d946049d25207848a9308e |
| 出典メモ | uspto-grants-2008_09 |