Hydrochloric Acid → 4-(2,2,2-Trifluoroethoxy)aniline

HRID 3055

反応式

HRID 3055 の反応式
[F:1][C:2]([F:15])([F:14])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([N+:11]([O-])=O)=[CH:7][CH:6]=1.C(O)C.Cl>O>[F:1][C:2]([F:14])([F:15])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 27757691-Nitro-4-(2,2,2-trifluoroethoxy)benzene

生成物 1

HCID 27771194-(2,2,2-Trifluoroethoxy)aniline収率 94%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

In a nitrogen atmosphere, 30.1 g (0.14 mol) of p-(2,2,2-trifluroethoxy) nitrobenzene, 82.1 g (1.47 mol) of reduced iron, 120 ml of ethanol and 40 ml of water were placed in a three-necked flask, to which 1.4 ml of concentrated hydrochloric acid was dropped under stirring and then refluxed for one hour. After cooling to a room temperature, it was separated by filtration, and the reaction solution was poured into iced water (about 2 liter), and precipitated solids were washed with water and then dried, to obtain 24.4 g (0.13 mol) of p-(2,2,2-trifluoroethoxy) aniline as pink solids. The yield was 94% and the melting point was 69.4° C.

後処理

  1. additionwas dropped
  2. temperaturerefluxed for one hour
  3. customit was separated by filtration
  4. additionthe reaction solution was poured into iced water (about 2 liter)
  5. customprecipitated solids
  6. washwere washed with water
  7. customdried

出典と根拠

ORDレコード
ord-785e0a0408f94a47b06e9ceee5b1cfa9
出典データセット
uspto-grants-1998_03
特許番号
US05733481

関連ノート

読み込み中…