Triethylamine → t-Butylpent-4-ynyloxy diphenyl silane

HRID 30585ノート

反応式

HRID 30585 の反応式
[C:1]([OH:6])#[C:2][CH2:3][CH2:4][CH3:5].[Si:7](Cl)([C:20]([CH3:23])([CH3:22])[CH3:21])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.CCN(CC)CC.C([O-])([O-])=O.[K+].[K+]>C(Cl)Cl>[C:20]([Si:7]([O:6][CH2:1][CH2:2][CH2:3][C:4]#[CH:5])([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)([CH3:23])([CH3:21])[CH3:22]

参加物

6

反応物 4

HCID 8471TriethylamineHCID 11430Potassium CarbonateHCID 94078tert-ButyldiphenylchlorosilaneHCID 10866258Pentynol

生成物 1

HCID 5461495t-Butylpent-4-ynyloxy diphenyl silane収率 98%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A mixture of pentynol (8.0 g, 95 mmol), t-butyldiphenylsilylchloride (28 g, 114 mmol) and Et3N (14 g, 138 mmol) in CH2Cl2 is stirred at room temperature for 16 h, treated with 1M K2CO3 and extracted with CH2Cl2. The combined extracts are dried over MgSO4 and concentrated in vacuo. The residue is purified by filtration on a silica pad to obtain 30 g of t-butylpent-4-ynyloxy diphenyl silane (yield: 98%

後処理

  1. extractionextracted with CH2Cl2
  2. dry with materialThe combined extracts are dried over MgSO4
  3. concentrationconcentrated in vacuo
  4. filtrationThe residue is purified by filtration on a silica pad

出典と根拠

ORDレコード
ord-a4503c5eb7224d55b81763f390f48172
出典データセット
uspto-grants-2008_09
特許番号
US07423158B2

反応ノート

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