化工社化工社 化学情報印刷レポート · 研究参考用
3,4-dihydro-2H-pyran → 2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-benzaldehyde
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3,4-dihydro-2H-pyran | HCID 8080 | — |
| 反応物 | 2,5-Dihydroxybenzaldehyde | HCID 70949 | — |
| 反応物 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 2-Hydroxy-5-(tetrahydro-pyran-2-yloxy)-benzaldehyde | HCID 19261361 | — |
反応手順
A solution of 2,5-dihydroxy-benzaldehyde (152 mmol), 3,4-dihydro-2H-pyran (167 mmol) and a catalytic amount of pyridinium p-toluenesulfonate in CH2Cl2 (480 mL) was left overnight at room temperature. The organic phase was washed with 1 N Na7CO3 (aq) (3×100 mL) and dried (Na2SO4). Evaporation in vacuo gave the desired product as brown crystals that was used without further purification. 1H-NMR (CDCl3) δ 10.72 (s, 1H), 9.88 (s, 1H), 7.32-7.29 (m, 2H), 6.96 (d, 1H), 5.38 (bs, 1H), 3.99-3.91 (m, 1H), 3.69-3.64 (m, 1H), 2.06-1.63 (m, 6H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423181B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-36d598fec8424eab88d7519ae21bb981 |
| 出典メモ | uspto-grants-2008_09 |