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4-Nitrobenzaldehyde → 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 4-Nitrobenzaldehyde | HCID 541 | — |
| 反応物 | Thiazolidinedione | HCID 5437 | — |
| 反応物 | Piperidine | HCID 8082 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-(4-Nitrobenzylidene)-1,3-thiazolidine-2,4-dione | HCID 2768264 | 59.2% |
反応手順
A mixture of 4-nitrobenzaldehyde (15.1 g), 1,3-thiazolidine-2,4-dione (11.70 g), piperidine (1.70 g) and ethanol (300 mL) was heated under reflux for 24 hrs. The reaction mixture was concentrated. The obtained residue was washed with ethanol to give 5-(4-nitrobenzylidene)-1,3-thiazolidine-2,4-dione as yellow crystals (14.8 g, yield 59%). Recrystallization thereof from acetone-hexane gave pale-yellow prism crystals. melting point: 272-273° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07423159B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-02854ddf1583494d8386c11c20c29345 |
| 出典メモ | uspto-grants-2008_09 |