[1-(4-nitrobenzyl)-1H-imidazol-2-yl]methanol → HCID 69208976、化合物
反応式
[N+:1]([C:4]1[CH:17]=[CH:16][C:7]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH2:14][OH:15])=[CH:6][CH:5]=1)([O-])=O>[C].[Pd].C(O)C>[NH2:1][C:4]1[CH:17]=[CH:16][C:7]([CH2:8][N:9]2[CH:13]=[CH:12][N:11]=[C:10]2[CH2:14][OH:15])=[CH:6][CH:5]=1参加物
4
実験手順
A mixture of [1-(4-nitrobenzyl)-1H-imidazol-2-yl]methanol (3.6 g), 10% palladium carbon (400 mg) and ethanol (50 ml) was stirred under a hydrogen atmosphere at room temperature for 4 hrs. Palladium carbon was removed from the reaction mixture by filtration, and the filtrate was concentrated. Recrystallization of the residue from ethyl acetate-hexane gave [1-(4-aminobenzyl)-1H-imidazol-2-yl]methanol (2.53 g, 95%) as colorless prism crystals. melting point: 125° C. (decomposition)
後処理
- customPalladium carbon was removed from the reaction mixture by filtration
- concentrationthe filtrate was concentrated
- customRecrystallization of the residue from ethyl acetate-hexane
出典と根拠
- ORDレコード
- ord-88fab999df784d1f9a32cb40afeafe81
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07423159B2
反応ノート
読み込み中…