Hydrochloric Acid → 4-Bromo-2-isopropylbenzoic acid
反応式
[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([O:8]C)=[O:7])=[C:4]([CH:12]([CH3:14])[CH3:13])[CH:3]=1.O.[OH-].[Li+].O1CCOCC1.Cl>O>[Br:1][C:2]1[CH:11]=[CH:10][C:5]([C:6]([OH:8])=[O:7])=[C:4]([CH:12]([CH3:14])[CH3:13])[CH:3]=1参加物
6
実験手順
A mixture of methyl 4-bromo-2-isopropylbenzoate (0.41 g) and lithium hydroxide monohydrate (0.67 g) in water (1 mL)/1,4-dioxane (3 mL) was stirred at room temperature for 5 days. 2 mol/L hydrochloric acid (10 mL) was added to the mixture, and the resulting mixture was extracted with ethyl acetate. The solvent was evaporated under reduced pressure, and the residue was recrystallized from ethyl acetate/n-hexane to afford the title compound (0.276 g).
後処理
- extractionthe resulting mixture was extracted with ethyl acetate
- customThe solvent was evaporated under reduced pressure
- customthe residue was recrystallized from ethyl acetate/n-hexane
出典と根拠
- ORDレコード
- ord-9fff2737c5dc4664b818f92fbba2d2d4
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07423185B2
反応ノート
読み込み中…