1-Bromo-2,4-difluorobenzene → 3(2,4-Difluorophenyl)thiophene

HRID 3076

反応式

HRID 3076 の反応式
F[C:2]1[CH:3]=[C:4]([C:10]2[CH:14]=[CH:13][S:12][CH:11]=2)[CH:5]=[C:6](F)[C:7]=1[F:8].BrC1C=CC([F:22])=CC=1F.BrC1C=C(F)C(F)=C(F)C=1>>[F:22][C:5]1[CH:6]=[C:7]([F:8])[CH:2]=[CH:3][C:4]=1[C:10]1[CH:14]=[CH:13][S:12][CH:11]=1

参加物

4

反応物 3

HCID 676741-Bromo-2,4-difluorobenzeneHCID 6114091-Bromo-3,4,5-trifluorobenzeneHCID 232955283-(3,4,5-Trifluorophenyl)thiophene

生成物 1

HCID 227436923(2,4-Difluorophenyl)thiophene収率 97%

反応条件

温度
80 °C

実験手順

The same procedures set forth above in Example (1)(a) for synthesizing 3(3,4,5-trifluorophenyl)thiophene were followed, with the exception that 1-bromo-2,4-difluorobenzene was substituted for 1-bromo-3,4,5-trifluorobenzene as the 1-bromo-substituted fluorobenzene, and the coupling reaction mixture was heated to reflux in an oil bath for 10 hours with stirring at 80° C. (as opposed to being heated in an oil bath for 0.5 hour with periodically stirring). No further purification by recrystallization was required to obtain a 97 to 98% pure product.

後処理

  1. customthe coupling reaction mixture
  2. temperaturewas heated
  3. temperatureto reflux in an oil bath for 10 hours
  4. temperatureto being heated in an oil bath for 0.5 hour
  5. stirringwith periodically stirring)
  6. customNo further purification
  7. customby recrystallization

出典と根拠

ORDレコード
ord-84962d33083243bb8070accd1465b529
出典データセット
uspto-grants-1998_03
特許番号
US05733683

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