化工社化工社 化学情報印刷レポート · 研究参考用
Ethanamine, 2,2,2-trifluoro- → (S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(2,2,2-trifluoro-ethyl)-malonamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Ethanamine, 2,2,2-trifluoro- | HCID 9773 | — |
| 反応物 | (R)-N-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid | HCID 58972476 | — |
| 生成物 | (S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(2,2,2-trifluoro-ethyl)-malonamide | HCID 58972465 | 58% |
反応手順
Using (R)—N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid and 2,2,2-trifluoro-ethylamine, the title compound was prepared in the same manner as described for example 1c. Final chromatography on silica (heptane/ethyl acetate gradient from 5 to 100%) afforded the title compound as white solid (58%). MS: m/e=558(M+H+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425551B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-60c6205f6fe749a0a251eee904ad5c40 |
| 出典メモ | uspto-grants-2008_09 |