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HRID 31036作成日：2026年10月26日

3,3,4,4,4-Pentafluorobutan-1-amine → (S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamide

https://huagongshe.com/reaction/31036

反応式

関与物質

役割名称HCID仕込み量
反応物3,3,4,4,4-Pentafluorobutan-1-amineHCID 15754740—
反応物(R)-N-[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acidHCID 58972476—
生成物(S)-N-[(S)-5-(2-Benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-N'-(3,3,4,4,4-pentafluoro-butyl)-malonamideHCID 58972468—

反応手順

Using (R)—N—[(S)-5-(2-benzyloxy-ethyl)-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-2-fluoro-2-methyl-malonamic acid and 3,3,4,4,4-pentafluoro-butylamine, the title compound was prepared in the same manner as described for example 1c. White solid (68%). MS: m/e=622(M+H+).

情報源と証拠

DOI10.6084/m9.figshare.5104873.v1
特許番号US07425551B2
出典データセットuspto-grants-2008_09
ORD IDord-c572702fc45e4494ba7c3bd7579f9e17
出典メモuspto-grants-2008_09