Triethylorthoaceate → 3-Isobutyl-8-methyl-2-thioxanthine
反応式
[NH2:1][C:2]1[C:3](=[O:14])[NH:4][C:5](=[S:13])[N:6]([CH2:9][CH:10]([CH3:12])[CH3:11])[C:7]=1[NH2:8].[CH2:15](C(CC)(CC)C([O-])([O-])[O-])[CH3:16]>>[CH2:9]([N:6]1[C:7]2[N:8]=[C:15]([CH3:16])[NH:1][C:2]=2[C:3](=[O:14])[NH:4][C:5]1=[S:13])[CH:10]([CH3:11])[CH3:12]参加物
3
反応条件
- 温度
- 130 °C
実験手順
A mixture of 5,6-diamino-1-isobutyl-2-thioxo-2,3-dihydro-1H-pyrimidin-4-one (Example 6 (c), 0.70 g, 3.26 mmol) and triethylorthoacetate (10 mL) was heated at 130° C. for 2 h and 40 minutes. Then the reaction mixture was cooled on an ice-bath, the solid filtered off and washed with ethanol (4×2 mL). The solid was dried in vacuo yielding the title compound (0.71 g, 95%).
後処理
- temperatureThen the reaction mixture was cooled on an ice-bath
- filtrationthe solid filtered off
- washwashed with ethanol (4×2 mL)
- customThe solid was dried in vacuo
出典と根拠
- ORDレコード
- ord-f521a926c71542608a44aad284863ad0
- 出典データセット
- uspto-grants-2008_09
- 特許番号
- US07425560B2
反応ノート
読み込み中…