Sulfuric Acid → 4,6-dimethyl-1H-indole-2,3-dione
反応式
[OH:1]S(O)(=O)=O.[CH3:6][C:7]1[CH:8]=[C:9]([NH:14][C:15](=[O:19])[CH:16]=NO)[CH:10]=[C:11]([CH3:13])[CH:12]=1>O>[CH3:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]2[C:8]=1[C:16](=[O:1])[C:15](=[O:19])[NH:14]2参加物
4
反応条件
- 温度
- 80 °C
実験手順
To a stirred warm (60°-70° C.) solution of concentrated H2SO4 (60 mL) and water (6 mL) was added in small portions N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide (15.0 g, 78 mM) so that the temperature of the reaction mixture did not exceed 70° C. After the addition was completed, the reaction mixture was heated at 80° C. for 10 min and then cooled and poured onto ice. The resulting mixture was filtered and the collected solids were washed with water and dried to provide the title compound (9.93 g, 72.6%); MS(CI): 176.
後処理
- customdid not exceed 70° C
- additionAfter the addition
- temperaturecooled
- additionpoured onto ice
- filtrationThe resulting mixture was filtered
- washthe collected solids were washed with water
- customdried
出典と根拠
- ORDレコード
- ord-d8484403e58847a9996f4809780dd83c
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733910
反応ノート
読み込み中…