Sulfuric Acid → 4,6-dimethyl-1H-indole-2,3-dione

HRID 3108

反応式

HRID 3108 の反応式
[OH:1]S(O)(=O)=O.[CH3:6][C:7]1[CH:8]=[C:9]([NH:14][C:15](=[O:19])[CH:16]=NO)[CH:10]=[C:11]([CH3:13])[CH:12]=1>O>[CH3:6][C:7]1[CH:12]=[C:11]([CH3:13])[CH:10]=[C:9]2[C:8]=1[C:16](=[O:1])[C:15](=[O:19])[NH:14]2

参加物

4

反応物 2

HCID 1118Sulfuric AcidHCID 53405864N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide

生成物 1

HCID 23861614,6-dimethyl-1H-indole-2,3-dione収率 72.6%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
80 °C

実験手順

To a stirred warm (60°-70° C.) solution of concentrated H2SO4 (60 mL) and water (6 mL) was added in small portions N-(3,5-dimethylphenyl)-2-(hydroxyimino)acetamide (15.0 g, 78 mM) so that the temperature of the reaction mixture did not exceed 70° C. After the addition was completed, the reaction mixture was heated at 80° C. for 10 min and then cooled and poured onto ice. The resulting mixture was filtered and the collected solids were washed with water and dried to provide the title compound (9.93 g, 72.6%); MS(CI): 176.

後処理

  1. customdid not exceed 70° C
  2. additionAfter the addition
  3. temperaturecooled
  4. additionpoured onto ice
  5. filtrationThe resulting mixture was filtered
  6. washthe collected solids were washed with water
  7. customdried

出典と根拠

ORDレコード
ord-d8484403e58847a9996f4809780dd83c
出典データセット
uspto-grants-1998_03
特許番号
US05733910

関連ノート

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