Acetic Acid → 4-Methoxy-2-nitrobenzoic acid

HRID 3111

反応式

HRID 3111 の反応式
[N+:1]([C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8]C=1C#N)([O-:3])=[O:2].[C:14]([OH:17])(=[O:16])[CH3:15].S(=O)(=O)(O)O>O>[N+:1]([C:4]1[CH:11]=[C:10]([O:12][CH3:13])[CH:9]=[CH:8][C:15]=1[C:14]([OH:17])=[O:16])([O-:3])=[O:2]

参加物

5

反応物 3

HCID 176Acetic AcidHCID 1118Sulfuric AcidHCID 2886654-Methoxy-2-nitrobenzonitrile

生成物 1

HCID 2886574-Methoxy-2-nitrobenzoic acid収率 91.8%

試薬・触媒・溶媒 1

HCID 962Water溶媒2 回

実験手順

A mixture of 2-nitro-4-methoxybenzonitrile (14.0 g, 78.6 mM) in a solution of acetic acid (28 mL), sulfuric acid (28 mL) and water (28 mL) was refluxed for 11 hr, allowed to cool and diluted with water (200 mL). The resulting precipitate which formed was collected, washed with water and dried to give the title benzoic acid (14.2 g, 91.8%) as a yellow crystalline solid; MS(CI): 198 (M+H).

後処理

  1. temperaturewas refluxed for 11 hr
  2. temperatureto cool
  3. customThe resulting precipitate which formed
  4. customwas collected
  5. washwashed with water
  6. customdried

出典と根拠

ORDレコード
ord-25ba7dfa0f824982b8c2a5e57de886c1
出典データセット
uspto-grants-1998_03
特許番号
US05733910

関連ノート

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