Water → 7-Iodo-1H-benzo[d][1,3]oxazine-2,4-dione
反応式
[I:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6](=[O:12])[C:7](=[O:11])[NH:8]2)=[CH:4][CH:3]=1.[OH2:13]>C(O)(=O)C.C(OC(=O)C)(=O)C.[O-2].[O-2].[O-2].[Cr+6]>[I:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[O:12])[O:11][C:7](=[O:13])[NH:8][C:9]=2[CH:10]=1参加物
6
反応条件
- 温度
- 80 °C
実験手順
To a stirred warm (80° C.) solution of 6-iodo-1H-indole-2,3-dione (3.0 g, 11 mM) in acetic acid (10 mL) and acetic anhydride (10 mL) was added in small portions chromium trioxide (1.83 g, 18.3 mM) while maintaining the temperature of the reaction mixture at 80°-90° C. The reaction mixture was then heated at 80° C. for 10 min, cooled and poured into water. The resulting mixture was filtered and the collected solids dried to provide the title compound as a yellow solid (2.6 g, 81.8%); MS(CI): 290 (M+H).
後処理
- temperaturewhile maintaining the temperature of the reaction mixture at 80°-90° C
- temperaturecooled
- filtrationThe resulting mixture was filtered
- customthe collected solids dried
出典と根拠
- ORDレコード
- ord-57ce19bea6534a878ad8a04143464a6c
- 出典データセット
- uspto-grants-1998_03
- 特許番号
- US05733910
反応ノート
読み込み中…