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2-Acetylhydroquinone → 2-(2,5-Difluorophenyl)-6-hydroxychroman-4-one
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Acetylhydroquinone | HCID 10279 | — |
| 反応物 | 2,5-Difluorobenzaldehyde | HCID 137663 | — |
| 反応物 | 2-(3-Fluorophenyl)-6-hydroxychroman-4-one | HCID 17978465 | — |
| 生成物 | 2-(2,5-Difluorophenyl)-6-hydroxychroman-4-one | HCID 17978591 | — |
反応手順
2-(2,5-Difluorophenyl)-6-hydroxychroman-4-one was prepared as described for 2-(3-fluorophenyl)-6-hydroxychroman-4-one in Example 9(a) starting from 3.0 g of 2′,5′-dihydroxyacetophenone and 2.57 ml of 2,5-difluorobenzaldehyde. The product was recrystallised from acetic acid. 1H NMR (300 MHz, d6-DMSO) δ: 9.46 (s, 1H), 7.53 (m, 1H), 7.36-7.30 (m, 2H), 7.14 (d, 1H, J 3.0 Hz), 7.05 (dd, 1H, J 8.8, 3.0 Hz), 6.97 (d, 1H, J 8.8 Hz), 5.76 (dd, 1H, J 13.6, 2.7 Hz), 3.26 (dd, 1H, J −16.8, 13.6 Hz), 2.76 (dd, 1H, J −16.8, 2.7 Hz).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07425568B2 |
| 出典データセット | uspto-grants-2008_09 |
| ORD ID | ord-7f50e63a1f3c495f9671f1a401ab4d73 |
| 出典メモ | uspto-grants-2008_09 |